TABLE 1.

NGS analyses of INDEL rates and base editing rates of EV‐delivered RNPs

		SpCas9
	SaCas9 IL2RG	DMD	GAPDH	P53	Site 5	ABE Site 5
GFP‐reporter cells	48.2%a	51.4%b	ND	ND	ND	ND
HEK293T	ND	ND	15.7%c	16.1%d	35.5%d	39.7%c
MDA‐MB‐231	ND	ND		14.4%d	33.8%d	24.2%c

For all assays, EVs were added to 2.5 × 10⁴ cells.

^aEVs produced by 0.6 million cells in 48 h were added to HBB‐IL2RG GFP‐reporter cells.

^bEVs produced by 2.5 million cells were added to DMD GFP‐reporter cells.

^cEVs produced by 5 million cells were added to the respective cells.

^dEVs produced by 20 million cells were added to the respective cells.