Table 1.

Outline of our institutional sex steroid supplementation regimen to treat PWS patients after establishing pubertal arrest and hypogonadism.

	Age (Years)	Dosage
Boys, testosterone enanthate	13–14.5	100 mg/4 weeks
	>14.5	250 mg/4 weeks
	>18	1000 mg/12 weeks
Girls, oestradiol	11–12	0.5 mg/day
	12–14	1.0 mg/day
	>14	Cyclic dosing of with E2 2 mg/day E2 for 12 days, followed by 2 mg E2 + norethisterone acetate 1 mg for the next 10 days and 1 mg E2 for the last 6 days

E2, oestrogen.