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Average particle size of acetaminophen-loaded NGO-PEG suspensions prepared using DoE.
| No. | NGO Sonication Time (hrs) | PEGylation Sonication Time (mins) | Stirring Time (mins) | Stirring Rate (rpm) | Average Size (nm) | Standard Deviation (SD) | PDI |
|---|---|---|---|---|---|---|---|
| 1 | 2 | 20 | 30 | 1500 | 209.1 | 3.0 | 0.18 |
| 2 | 2 | 20 | 30 | 500 | 1129.0 | 35.4 | 0.76 |
| 3 | 2 | 10 | 30 | 1500 | 880.8 | 31.2 | 0.40 |
| 4 | 2 | 10 | 30 | 500 | 1356.0 | 56.0 | 0.83 |
| 5 | 1 | 20 | 30 | 1500 | 278.3 | 8.3 | 0.37 |
| 6 | 1 | 20 | 30 | 500 | 641.9 | 14.3 | 0.26 |
| 7 | 1 | 10 | 30 | 1500 | 749.9 | 27.8 | 0.63 |
| 8 | 1 | 10 | 30 | 500 | 834.5 | 21.0 | 0.80 |
