Table 2.

Design of experiment (DoE) for the preparation of acetaminophen (AMP)-loaded PEGylated nano graphene oxide (NGO) batches.

Batch	Sonication Duration to Produce Nano GO	Sonication Duration to Produce PEGylated Nano GO	Stirring Rate	Stirring Time
1	H	H	H	H
2	H	H	H	L
3	H	H	L	L
4	H	L	L	L
5	L	L	L	L
6	L	L	L	H
7	L	L	H	H
8	L	H	H	H
9	H	L	H	H
10	H	L	H	L
11	H	L	L	H
12	L	H	L	H
13	L	H	H	L
14	L	L	H	L
15	H	H	L	H
16	L	H	L	L