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. 2021 Mar 16;21:169. doi: 10.1186/s12935-021-01845-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The effects of CDC42EP3 knockdown on cell proliferation, colony formation and cell apoptosis. a MTT was performed to estimate the effects of CDC42EP3 knockdown on cell proliferation. b EdU staining was performed to show the proliferative activity of RKO and HCT116 cells with or without CDC42EP3 knockdown. c Number of colonies formed by RKO and HCT116 cells with or without CDC42EP3 knockdown was counted. d Flow cytometry was employed to evaluate the cell apoptosis of RKO and HCT116 cells with or without CDC42EP3 knockdown. e Human Apoptosis Antibody Array was utilized to identify differentially expressed apoptosis-related proteins, by which CDC42EP3 regulated cell apoptosis. The representative images were randomly selected from at least 3 independent experiments in duplicate. *P < 0.05, **P < 0.01, ***P < 0.001