Table 4.

Incident CVD hazard ratios for epigenetic age acceleration in GENOA African Americans

Epigenetic age acceleration (predictor)	HR (95% CI)	P value
IEAA	0.97 (0.93–1.02)	0.300
EEAA	1.04 (1.00–1.08)	0.057
PhenoAA	1.00 (0.97–1.04)	0.810
GrimAA	1.09 (1.04–1.15)	4.20 × 10–4

Models are adjusted for age, sex and familial relatedness

CVD, cardiovascular disease; HR, hazard ratio; IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration

Hazard ratios correspond to the risk of a CVD event associated with a 1-year increase in the epigenetic age acceleration measure

Cardiovascular disease (CVD) was defined as self-reported myocardial infarction, coronary artery revascularization, cerebrovascular events, or surgical carotid artery revascularization

Associations significant at P < 0.05 are shown in bold