Fig. 3.

Inhibition of PAD4 promotes the radiosensitivity and cellular processes in NPC. a, b The PAD4 level after treatment with GSK484 by RT-qPCR and western blot. c Colony formation assay of NPC cells treated with different concentrations of GSK484. One‑way ANOVA with Tukey’s post hoc test. d Cell proliferation in NPC cells treated with GSK484 or not by EdU assay, at 24 h after 6 Gy irradiation. e, f Migration and invasion in NPC cells treated with GSK484 or not by wound healing and Transwell assays, at 24 h after 6 Gy irradiation. g The level of citH3 protein in NPC cell treated with GSK484 or not was measured by western lot. Unpaired Student’s test. *p < 0.05, **p < 0.01