Table 1.
Sociodemographic, clinical characteristics and HPV profile of cases by histological grade and age group (Guadeloupe, 2014–2016)
| Overall | CIN 2/3 grades | Invasive cancers | p | < 40 years | 41–50 years | > 50 years | p | |
|---|---|---|---|---|---|---|---|---|
| n = 213 | n = 184 | n = 29 | n = 111 | n = 56 | n = 46 | |||
| Year of diagnosis, n(%) | 0.53 | 0.25 | ||||||
| 2014 | 98 (46) | 82 (45) | 16 (55) | 44 (40) | 27 (48) | 27 (59) | ||
| 2015 | 50 (23) | 45 (24) | 5 (17) | 29 (26) | 14 (25) | 7 (15) | ||
| 2016 | 65 (31) | 57 (31) | 8 (28) | 38 (34) | 15 (27) | 12 (26) | ||
| HPV status, n(%) | 0.67 | 0.33 | ||||||
| HPV- | 12 (6) | 10 (5) | 2 (7) | 6 (5) | 5 (9) | 1 (2) | ||
| HPV+ | 201 (94) | 174 (95) | 27 (93) | 105 (95) | 51 (91) | 45 (98) | ||
| n = 188 | n = 162 | n = 26 | n = 97 | n = 48 | n = 43 | |||
| Profile of infectiona, n(%) | 0.002 | 0.99 | ||||||
| 1 virus | 34 (18.1) | 32 (19.7) | 2 (7.7) | 18 (18.6) | 9 (18.7) | 7 (16.3) | ||
| 2 to 3 virus | 66 (35.1) | 49 (30.2) | 17 (65.4) | 33 (34.0) | 17 (35.4) | 16 (37.2) | ||
| > 3 virus | 88 (46.8) | 81 (50.0) | 7 (26.9) | 46 (47.4) | 22 (45.8) | 20 (46.5) | ||
| HPV oncogenicity riska, n(%) | ||||||||
| High-risk | 183 (91) | 157 (91) | 26 (93) | 0.77 | 93 (84) | 48 (86) | 42 (91) | 0.48 |
| Probable High risk | 104 (52) | 90 (52) | 14 (50) | 0.95 | 52 (47) | 27 (48) | 25 (54) | 0.69 |
| Low risk and others | 101 (51) | 84 (49) | 17 (61) | 0.92 | 52 (47) | 24 (43) | 25 (54) | 0.50 |
| HR-HPV in combinationa, n(%) | 0.6 | 0.7 | ||||||
| No HR | 5 (2.7) | 5 (3.1) | 0 | 4 (4.1) | 0 | 1 (2.3) | ||
| 1 HR | 58 (30.8) | 48 (29.6) | 10 (38.5) | 28 (28.9) | 17 (35.4) | 13 (30.2) | ||
| 2–3 HR | 91 (48.4) | 80 (49.4) | 11 (42.3) | 45 (46.4) | 23 (47.9) | 23 (53.5) | ||
| > 3 HR | 34 (18.1) | 29 (17.9) | 5 (19.2) | 20 (20.6) | 8 (16.7) | 6 (13.9) | ||
a Proportions are calculated after excluding positive cases with missing data for genotypes and negative cases