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. 2021 Mar 16;16:18. doi: 10.1186/s13027-021-00357-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Functional Prediction of the Key Genes Involved in HBV Associated HCC. a Protein-Protein-Interaction (PPI) Network of the Key Genes Involved in HBV Associated HCC. GeneMANIA was applied to predict the function of key genes and construct the PPI network. The red rounds indicated key genes (query genes), and the khaki rounds indicated result genes. The different color lines between the rounds indicated distinct relationships between corresponding genes/proteins, such as co-expression, co-localization, physical interactions, predicted relations, shared protein domains, genetic interactions and pathway. b Visualization of the CELL CYCLE (hsa04110) KEGG pathway. The genes in the PPI network are highlighted in red. The different relations between proteins in the pathway are indicated in distinct types of lines. c The VIRAL CARCINOGENESIS pathways (hsa05203) related to the genes in PPI network. The genes in the PPI network are also highlighted in red