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. 2021 Mar 16;14:80. doi: 10.1186/s12920-021-00921-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Correlation plots of the prevalence of open-angle glaucoma with intraocular pressure and genetic risk score using related single nucleotide polymorphisms. a The genetic risk score of OAG with high IOP according to populations of different ancestry was highest in Europeans, followed by South Asians, Africans, and East Asians. b The prevalence of OAG with elevated IOP was positively correlated with the population average genetic risk score (R = 0.699). The prevalence of open-angle glaucoma with normal intraocular pressure (normal-tension glaucoma) in AMR was excluded from the analysis since there were not enough research results. AMR: American, EUR: Europeans, SAS: South Asians, AFR: Africans, EAS: East Asians. ACB: African Caribbean in Barbados, ASW: African Ancestry in Southwest US, BEB: Bengali in Bangladesh, CDX: Chinese Dai in Xishuangbanna, CEU: Utah residents with Northern and Western European ancestry, CHB: Han Chinese in Beijing, China, CHS: Southern Han Chinese, China, CLM: Colombian in Medellin, Colombia, ESN: Esan in Nigeria, FIN: Finnish in Finland, GBR: British in England and Scotland, GIH: Gujarati Indian in Houston, TX, GWD: Gambian in Western Division, The Gambia, IBS: Iberian populations in Spain, ITU: Indian Telugu in the UK, JPT: Japanese in Tokyo, Japan, KOR: Korean in Republic Korea, KHV: Kinh in Ho Chi Minh City, Vietnam, LWK: Luhya in Webuye, Kenya, MSL: Mende in Sierra Leone, MXL: Mexican Ancestry in Los Angeles, California, PEL: Peruvian in Lima, Peru, PJL: Punjabi in Lahore, Pakistan, PUR: Puerto Rican in Puerto Rico, STU: Sri Lankan Tamil in the UK, TSI: Toscani in Italy, YRI: Yoruba in Ibadan, Nigeria