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. 2021 Mar 2;11:595471. doi: 10.3389/fphar.2020.595471

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Copyright © 2021 Kumar, Chowdhury, Razdan, Kumari, Purty, Ram, Kumar, Nayak and Shukla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene Expression analysis in the cerebral cortex brain tissue of rat (NORMAL GP = Control group; STZ = Streptozotocin treated group; SITA + STZ = Streptozotocin and sitagliptin treated group; PIPERINE + STZ = Streptozotocin and piperine treated group). In compared to the untreated control group, the expression of BACE1, PSEN1, APAF1, CASPASE3, and CATALASE genes were significantly upregulated (p ≤ 0.05) in STZ treated group (Diabetes control). However, when the STZ treated group (Diabetes control) was treated with either sitagliptin (Positive control) or piperine, the expression of all the five genes were significantly down-regulated (p ≤ 0.05). Data are presented as mean ± SD. **p < 0.01 with the control (NORMAL GP).