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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Pain. 2020 Oct;161(10):2344–2352. doi: 10.1097/j.pain.0000000000001921

Figure 6.

Figure 6.

Genetic deletion of Il10ra from Advillin-positive sensory neurons delays the resolution of cisplatin-induced mechanical hypersensitivity. A. Mechanical pain threshold in control (Il10rafloxflox) and Il10raDRG-KO mice after cisplatin treatment (2 mg/kg daily for 3 days) (n= 3F+4M/group), repeated measure two-way ANOVA interaction time x genotype F (8,72) = 5.09, p<0.0001. Resolution of mechanical pain threshold is delayed in mice that lack IL-10R1 on sensory neurons while baseline pain thresholds and severity of mechanical pain were similar in both genotypes. B. Mechanical sensitivity measured by von Frey hairs in female and male Il10raDRG-KO mice in response to cisplatin. Data are shown as mean ± SEM.