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. 2021 Mar 2;12:645320. doi: 10.3389/fimmu.2021.645320

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Copyright © 2021 Zhang, Wang, Wang, Zhao, Zhang, Zhang and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between the risk model and clinical factors. (A, B) Single-factor prognostic analysis included age, sex, tumor–node–metastasis (TNM) stage, and the risk scores of patients with colorectal cancer in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. (C, D) Multifactor prognostic analysis included age, sex, TNM stage, and the risk scores of patients with colorectal cancer in TCGA and GEO databases. (E, F) Comparisons of the expression levels of various genes in the hypoxia model in TCGA and GEO databases for different T stages. (G, H) Heat maps showing the expression levels of genes in the risk model in TCGA and GEO databases for different T stages.