Table 1.
Pathway enrichment in the group of patients at high risk of hypoxia in The Cancer Genome Atlas database.
| NAME | SIZE | ES | NES | NOM p-val | FDR q-val | FWER p-val |
|---|---|---|---|---|---|---|
| MYOGENESIS | 199 | 0.64095765 | 2.2988102 | 0 | 0 | 0 |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 198 | 0.7808052 | 2.2663856 | 0 | 9.73E-04 | 0.001 |
| COAGULATION | 138 | 0.5881612 | 2.2491221 | 0 | 6.49E-04 | 0.001 |
| APICAL_JUNCTION | 200 | 0.5725273 | 2.210138 | 0 | 7.86E-04 | 0.002 |
| HYPOXIA | 197 | 0.5341002 | 2.1750667 | 0 | 0.001029189 | 0.003 |
| ANGIOGENESIS | 36 | 0.7042173 | 2.1259532 | 0 | 0.002047737 | 0.007 |
| KRAS_SIGNALING_UP | 199 | 0.53099084 | 2.0836837 | 0 | 0.003663993 | 0.015 |
| UV_RESPONSE_DN | 142 | 0.5923043 | 2.0315046 | 0.001988072 | 0.00553734 | 0.022 |
| HEDGEHOG_SIGNALING | 36 | 0.6280092 | 2.0067165 | 0.003913894 | 0.005807516 | 0.026 |
| RESPONSE | 200 | 0.5912703 | 2.0001185 | 0.003738318 | 0.005448199 | 0.027 |
| COMPLEMENT | 200 | 0.5222255 | 1.9398772 | 0.001926782 | 0.008785588 | 0.045 |
| IL2_STAT5_SIGNALING | 199 | 0.47638285 | 1.9347376 | 0.001923077 | 0.008227405 | 0.047 |
| NOTCH_SIGNALING | 32 | 0.53026545 | 1.8844135 | 0.005928854 | 0.011401303 | 0.078 |
| APICAL_SURFACE | 44 | 0.52808076 | 1.8692672 | 0 | 0.012468602 | 0.085 |
| APOPTOSIS | 159 | 0.45459515 | 1.8656777 | 0.003846154 | 0.012308807 | 0.089 |
| TNFA_SIGNALING_VIA_NFKB | 199 | 0.5475131 | 1.8406801 | 0.009380863 | 0.014613844 | 0.114 |
| IL6_JAK_STAT3_SIGNALING | 87 | 0.5565036 | 1.7961316 | 0.0056926 | 0.020605113 | 0.158 |
| TGF_BETA_SIGNALING | 54 | 0.47515002 | 1.6418401 | 0.034951456 | 0.059671924 | 0.381 |
| ALLOGRAFT_REJECTION | 196 | 0.5172241 | 1.5929213 | 0.06 | 0.07578372 | 0.456 |
| WNT_BETA_CATENIN_SIGNALING | 42 | 0.47698218 | 1.5757742 | 0.045454547 | 0.079787806 | 0.484 |
| ESTROGEN_RESPONSE_EARLY | 198 | 0.32408136 | 1.4306225 | 0.055984557 | 0.15474646 | 0.701 |
| CHOLESTEROL_HOMEOSTASIS | 73 | 0.38557705 | 1.4078543 | 0.10685484 | 0.16225821 | 0.734 |
| KRAS_SIGNALING_DN | 199 | 0.34252158 | 1.3754886 | 0.07129095 | 0.17926803 | 0.779 |
| UV_RESPONSE_UP | 156 | 0.28952506 | 1.2597458 | 0.12741312 | 0.27369708 | 0.891 |
| INTERFERON_GAMMA_RESPONSE | 198 | 0.4217492 | 1.2542942 | 0.2848723 | 0.2676427 | 0.894 |
| MITOTIC_SPINDLE | 198 | 0.31854162 | 1.188202 | 0.31697342 | 0.3293753 | 0.935 |
| P53_PATHWAY | 195 | 0.27196786 | 1.1832048 | 0.21314742 | 0.3224601 | 0.937 |
| ADIPOGENESIS | 198 | 0.27874216 | 1.1698754 | 0.27734375 | 0.32397935 | 0.943 |
| GLYCOLYSIS | 199 | 0.26324964 | 1.1427033 | 0.26070037 | 0.34104726 | 0.956 |
| ANDROGEN_RESPONSE | 99 | 0.30673286 | 1.1124011 | 0.33870968 | 0.36284208 | 0.966 |
| ESTROGEN_RESPONSE_LATE | 198 | 0.2458808 | 1.1081452 | 0.2615694 | 0.35552585 | 0.967 |
| HEME_METABOLISM | 193 | 0.23562211 | 1.0899739 | 0.30113637 | 0.36277255 | 0.972 |
| MTORC1_SIGNALING | 197 | 0.24964637 | 0.90750676 | 0.5214724 | 0.5825153 | 0.997 |
| PI3K_AKT_MTOR_SIGNALING | 105 | 0.209095 | 0.88849974 | 0.634 | 0.59227496 | 0.997 |
| PANCREAS_BETA_CELLS | 40 | 0.23578233 | 0.70691955 | 0.8606061 | 0.83144087 | 1 |
| INTERFERON_ALPHA_RESPONSE | 96 | 0.19630556 | 0.54184294 | 0.8392157 | 0.95013 | 1 |