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. 2021 Apr;27(4):420–432. doi: 10.1261/rna.077198.120

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© 2021 Karasik et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 1. — Locations of the investigated mitochondrial tRNA mutations in the predicted secondary structure of (A) (mt)pre-tRNA^Ile, (B) (mt)pre-tRNA^Leu(UUR), and (C) (mt)pre-tRNA^Met. Circles indicate methylation sites for the MRPP1/2 subcomplex. (D) Location of the mutations in the L-shaped tertiary structure of tRNAs. High-resolution structure of the investigated tRNAs are not available, therefore we used a conserved eukaryotic tRNA^Phe with known structure (PDB ID: 1ehz) for generating the figure. Mutations are color coded according to the colors shown in A, B, and C. Purple represents mutation at the same position in (mt)pre-tRNA^Leu(UUR) (U3290C) and (mt)pre-tRNA^Ile (A4317G). We also note that the D-loop for (mt)pre-tRNA^Leu(UUR) and (mt)pre-tRNA^Met is different in length from most canonical tRNAs and therefore the elbow region may fold differently than modeled here.