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. 2021 Apr;27(4):420–432. doi: 10.1261/rna.077198.120

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© 2021 Karasik et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 4. — Disease-associated tRNA mutations alter the structure of pre-tRNAs. (A) Representative UV melting profile curves for the wild-type and mutant (mt)pre-tRNA^Ile variants. (B,C) Representative UV melting profile curves of wild-type and mutant (mt)pre-tRNA^Leu(UUR)s. (D) Representative UV melting profile curves of wild-type and mutant (mt)pre-tRNA^Mets.