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. 2021 Mar 8;22(5):2716. doi: 10.3390/ijms22052716

Figure 5.

Figure 5

Perlecan interacts with cell surface integrins and type XI collagen in the PCM. (a) Diagrammatic schematic representation of the interaction of perlecan with cell surface integrins and the HSbinding sites of type XI collagen at the ovine disc cell surface. (b,c) Immunoperoxidase localisation of type XI collagen (b) and perlecan HS (c) in monolayer cultures of annulus fibrosus cells. (d) Schematic of the HS binding sites on the exposed Npp α1 domain of a type XI collagen heterofibril (e) Immunofluorescence localisation of type XI collagen in cultured chondrosarcoma cells showing pericellular HS-PGs. Segments a-c reproduced from [63]. Segments d and e reproduced from [64]. All plates in (e) are provided at the same magnification, 20 µm scale bar applicable to all segments.