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. 2021 Mar 16;184(10):2605–2617.e18. doi: 10.1016/j.cell.2021.03.027

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Neutralization escape from monoclonal antibodies

(A) Table showing IC₅₀ values for pseudotype neutralization tests with the indicated SARS-CoV-2 S pseudotypes. Monoclonal antibody names are abbreviated (e.g., C1A-gl is “gl” and C1A-B3 is “B3”). Antibodies are listed, left to right, in order of increasing affinity. IC₅₀ values for an ACE2-Fc neutralization assay done as part of the same experiment are shown. See also Figure S2C.

(B) Summary of results shown in (A) highlighting the fraction of resistant monoclonal antibodies for each S pseudotype.

(C) Table showing IC₅₀ values for SARS-CoV-2 S pseudotype neutralization tests with the indicated monoclonal antibodies. IC₅₀ values for an ACE2-Fc neutralization assay done as part of the same experiment are shown. See also Figures S2D and S2E.

(D) Ribbon diagram of the SARS-CoV-2 RBD bound to Fabs for antibodies REGN10987 and REGN10933 (PDB: 6XDG) (Hansen et al., 2020). Mutated residues of interest are shown as in Figure 3C, with the exception of residue N439_RBD (shown as light blue spheres).

See also Figure S5 and Table S4.