Figure 7.

S2X333 provides robust in vivo protection against SARS-CoV-2 challenge but selects for escape mutants

Syrian hamsters were injected with the indicated amount of mAb 48 h before intra-nasal challenge with SARS-CoV-2.

(A) Quantification of viral RNA in the lungs 4 days post-infection.

(B) Quantification of replicating virus in lung homogenates harvested 4 days post-infection using a TCID₅₀ assay.

(C and D) Viral RNA loads and replicating virus titers in the lung 4 days post-infection plotted as a function of serum mAb concentrations before infection (day 0). Mann-Whitney test was used. ^∗p < 0.05, ^∗∗p < 0.01. Data from two independent experiment are presented. (Irrelevant mAb n = 8; S2X333 1 mg/kg n = 9; S2X333 4 mg/kg n = 9).

See also Figure S6.