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. 2021 Mar 16;184(9):2316–2331.e15. doi: 10.1016/j.cell.2021.03.029

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Figure S1 — Competition binding of NTD-reactive MAbs, related to Figure 1

(A) Competition of the panel of neutralizing mAbs with reference mAbs COV2-2676 and COV2-2263. Binding of reference mAbs to trimeric

S6P_ecto was measured in the presence of a saturating concentration of competitor mAb in a competition ELISA and normalized to binding in the presence of rDENV-2D22. Black indicates full competition (< 25% binding of reference antibody); gray indicates partial competition (25 to 60% binding of reference antibody); white indicates no competition (> 60% binding of reference antibody).

(B) Inhibition of mAb COV2-2676 (left) or COV2-2489 (right) binding in ELISA to SARS-CoV-2 S6P_ecto by serum or plasma of nine SARS-CoV-2 immune individual or one non-immune control individual. Data are mean ± SD of triplicates and are representative of two experiments with similar results. Dotted line indicates the percentage of self-competition of mAbs COV2-2676 and-2489 on the SARS-CoV-2 S6P_ecto antigen.