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. 2021 Mar 2;11:628653. doi: 10.3389/fonc.2021.628653

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Copyright © 2021 Bergqvist, Elebro, Borgquist and Rosendahl

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modulation of kinase phosphorylation profiles and associated biological processes in estrogen receptor positive T47D breast cancer cells in response to adipocyte secretome from obese- compared with normal conditions. (A) Graph shows fold changes of phosphorylation pattern in T47D cells following exposure to adipocyte conditioned media (ACM) from obese relative to normal conditions. Phosphorylation patterns modulated ≥ 1.25-fold are shown. (B) Bubble plot shows the fold enrichment of biological processes over-represented among enhanced phosphorylated kinases. False discovery rate (FDR) < 5%.