Table 4.
Clinical trial data of exosomes used to treat various diseases.
| Exosome Source | Condition | Payload | Phase, Patients | Clinical Trial Identifier |
|---|---|---|---|---|
| MSCs | Multiple organ failure | NA | NA (n = 60) | NCT04356300 |
| Severe COVID-19 Pneumonia |
NA | Phase 1 (n = 24) | NCT04276987 | |
| Periodontitis | NA | Phase 1 (n = 10) | NCT04270006 | |
| Dry Eye | NA | Phase 1 (n = 27) | NCT04213248 | |
| Type I Diabetes Mellitus | NA | Phase 1 (n = 20) | NCT02138331 | |
| Metastatic Pancreatic cancer |
KRAS G12D siRNA |
Phase 1 (n = 28) | NCT03608631 | |
| Macular Holes | NA | Phase 1 (n = 44) | NCT03437759 | |
| Cerebrovascular disorders | NA | Phase 1/2 (n = 5) | NCT03384433 | |
| Diabetic Nephropathy | Placebo | NA (n = 38) | NCT04562025 | |
| Dendritic Cell | Sepsis | Antibiotics | NA (n = 50) | NCT02957279 |
| Non-small cell lung cancer | Antigens | Phase 2 (n = 41) | NCT01159288 | |
| MAGE tumor antigens | ||||
| Metastatic melanoma | MAGE 3 peptides | |||
| Plant | Colorectal cancer | Curcumin | Phase 1 (n = 7) | NCT01294072 |
| Obesity | NA | NA (n = 160) | NCT02706262 | |
| Head & Neck cancer | Grape extract | Phase I (n = 60) | NCT01668849 | |
| Polycystic ovary syndrome | Ginger & Aloe | NA (n = 176) | NCT03493984 |
Source: https://www.clinicaltrials.gov (accessed on 24 December 2020). NA = Not available.