Table 3.

Univariate and multivariable Cox proportional hazard models for the NYU BRAF-targeted therapy cohort in metastatic melanoma

Variable	Melanoma-specific survival
	HR (95% CI)	P*
Univariate Cox proportional hazard model
NM vs SSM	2.89 (1.36 to 6.14)	.006
Multivariable Cox proportional hazard model
NM vs SSM	3.33 (1.06 to 10.47)	.04
Age at primary diagnosis†	1.20 (0.95 to 1.53)	.13
Sex	1.29 (0.52 to 3.18)	.58
Primary thickness	1.04 (0.95 to 1.14)	.37
Primary ulceration	0.84 (0.30 to 2.36)	.74
Primary mitotic index	7.42 (0.92 to 59.51)	.06
Primary Dx stage II	0.76 (0.14 to 4.22)	.76
Primary Dx stage III	1.41 (0.40 to 4.93)	.59

^*All statistical tests are two-sided. CI = confidence interval; HR = hazard ratio; NM = nodular melanoma; SSM = superficial spreading melanoma.

^†Reported HRs calculated per 10 years of age.