Table 1.

Summary table of identified E2 enzymes and their functional roles in melanoma.

E2 Class		E2s	Roles in Melanoma	Refs
I		UBE2N UBE2I UBE2B	Overexpressed, proliferation and malignancy Proliferation, apoptosis evasion, sumoylation of MITF Overexpressed, progression and pathogenesis	[39] [44,45,46,47] [50,51]
II		UBE2C	Overexpressed, associated with poor prognosis	[40,41]
III		UBE2T UBE2S	Overexpressed, biological role to be determined Proliferation, cell survival, tumor growth, EMT	[35] [49]
IV