Figure 3.

Virulence factors that affect apoptosis, cell proliferation, or asymmetric cell division studied in Drosophila. (A) Pathogenic proteins and their targets that affect apoptosis. Bacterial and viral proteins that induce apoptosis through activation of stress signaling pathways are not depicted here (see Figure 2 for these) (B) Pathogenic proteins and their targets that affect cell proliferation. (C) Pathogenic proteins and their targets that affect asymmetric cell division. Host proteins shown in cool colors and pathogenic proteins (3a (SARS-CoV-1), AopP (A. salmonicida), BRLF1 (EBV), BZLF1 (EBV), M (SARS-CoV-1), NS4A (ZIKV), ST (SV40), and Vpu (HIV)) are shown in warm colors.