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. 2021 Mar 2;11:614458. doi: 10.3389/fonc.2021.614458

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Copyright © 2021 Cao, Zhao, Yang, Shi, Liu, Pan, Zhou and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of chidamide (CHI) and/or doxorubicin (DOX) on the proliferation and cell cycle of multidrug-resistant (MDR) breast cancer cells. (A) Drug resistance clonogenic assay confirmed the effect of CHI and/or DOX on cell proliferation. (B) EDU staining confirmed the effect of CHI and/or DOX on cell proliferation. (C) Effects of CHI and/or DOX on cell cycle. Numerical values are expressed as mean ± SD of three independent replicates. “*” indicates a significant difference compared with the control group (*P < 0.05, **P < 0.01),”#” indicates a significant difference compared with the DOX-treated group (^###P<0.001), and “&” indicates a significant difference compared with the CHI-treated group (^&P<0.05).