Table 1.

Tumor-Promoting Roles of Frizzled Proteins (Fzds)

Fzds	Wnt Pathways	Malignant Tumors	Functions	References
Fzd1	Canonical	NB, breast cancer, AML	Chemoresistance	55–58
Fzd2	Noncanonical	Liver, breast, colon, lung cancers	EMT, metastasis, stemness	38, 40, 45
Fzd7	Canonical	Liver, breast cancers	Growth, stemness	59–62
Fzd3	Noncanonical	Melanoma	Stemness, metastasis	69
Fzd6	Noncanonical	NB, TNBC	Stemness, metastasis, chemoresistance	70, 71
Fzd5	Canonical	Endometrial, ovarian, pancreatic cancers	Growth	72–74
	Noncanonical	Melanoma, cHL	Migration, invasion	27, 75
Fzd8	Canonical	HNSCC, TNBC	Stemness, metastasis, chemoresistance	76, 77
	Noncanonical	Prostate cancer	EMT, metastasis	50
Fzd4	Canonical	GBM, prostate cancer	EMT, stemness	78, 79
Fzd10	Canonical	Breast, ovarian cancers	EMT, chemoresistance	80–82