Figure 1.

A: Schematic showing structural changes present in the spike protein of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants identified in the study. B: Mapping of important changes onto the cryoEM structure of spike protein. The color scheme matches that used in A. Blue, amino-terminal domain (NTD); purple, receptor-binding domain (RBD); orange, S1 domain (S1); and yellow, S2 domain (S2). Aggregate mutations present in variants of concern are colored in red when amino acid residues are present in the resolved structure. Left panel: Side view of SARS-CoV-2 prefusion-stabilized spike. Right panel, top view: Structure of PDB 6vsb was used as reference.