Table 4.
Particle size and emulsifier content in the aqueous phase of emulsions.
PCS z-Average Diameter |
PCS PdI |
Emulsifier Content in the Aqueous Phase | Lipid Content after Production | |
---|---|---|---|---|
Kinetics of drug loading, influence of the type of lipid matrix and influence of drug load on emulsion stability | ||||
SB-P188-120 nm | 122 nm | 0.13 | 0.8% | n.d. |
TM-P188-120 nm | 119 nm | 0.12 | 2.5% | n.d. |
RS-P188-120 nm | 124 nm | 0.12 | 1.0% | n.d. |
MCT-P188-120 nm | 117 nm | 0.11 | 2.0% | n.d. |
SB-P407-130 nm | 128 nm | 0.11 | 0.2% | n.d. |
Drug localization | ||||
SB-P188-70 nm | 69 nm | 0.11 | n.d. | 8.9% |
SB-P188-150 nm | 151 nm | 0.14 | 1.6% | 8.6% |
SB-P188-230 nm | 233 nm | 0.02 | n.d. | 7.9% |
n.d. not determined; PCS: photon correlation spectroscopy.