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. 2021 Mar 8;22(5):2728. doi: 10.3390/ijms22052728

Figure 7.

Figure 7

The fasting-induced reversal of the PACAP response in POMC neurons is also dependent upon activation of AMPK. The outward current caused by PACAP under fasting conditions in POMC neurons (A; n = 12) is transformed into an inward current in the presence of the AMPK inhibitor Compound C (30 μM; B; n = 8) The PACAP-induced outward current in (A) was reproduced under ad libitum-fed conditions in the presence of the AMPK activator metformin (500 μM; C; n = 10). The data from these representative traces is summarized in composite form by the bar graph in (D) and the pie charts in (E–G). Bars represent means and lines 1 SEM. *, p < 0.05 relative to PACAP alone, one-way ANOVA/LSD.