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. 2021 Mar 16;138:111469. doi: 10.1016/j.biopha.2021.111469

Table 1.

Baseline demographic and clinical characteristics according to chronic RASI therapy at admission.

OVERALL POPULATION (N = 6095)
YEAR 2019 (N = 3389)
YEAR 2020 (N = 2706)
RASI (n = 2441) No RASI 2019 (n = 3654) P value RASI (n = 1375) No RASI 2019 (n = 2014) P value RASI (n = 1066) No RASI 2020 (n = 1640) P value
Age (median, IQR) 67 [58–75] 62 [53–71] < 0.001 67 [58–75] 62 [53–71] < 0.001 67 [59–75] 62 [53–71] < 0.001
Age > 75 year – n. (%) 664 (27.2) 633 (17.6) < 0.001 373 (27.1) 358 (17.8) < 0.001 291 (27.3) 275 (16.8) < 0.001
Male gender – n. (%) 1801 (71.3) 2870 (75.8) < 0.001 969 (70.5) 1527 (75.8) 0.001 765 (71.8) 1256 (76.6) 0.005
Diabetes Mellitus- n (%) 758 (31.1) 568 (15.5) < 0.001 428 (31.1) 316 (15.7) < 0.001 330 (31) 252 (15.4) < 0.001
Hypertension- n (%) 2170 (88.9) 1148 (31.4) < 0.001 1234 (89.7) 634 (31.5) < 0.001 936 (87.8) 514 (31.3) < 0.001
Hypercholesterolemia - n (%) 1225 (50.2) 1350 (36.9) < 0.001 679 (49.4) 739 (36.7) < 0.001 546 (51.2) 611 (37.3) < 0.001
Active Smokers – n (%) 895 (36.7) 1639 (44.9) < 0.001 514 (37.4) 901 (44.7) < 0.001 381 (35.7) 738 [45] < 0.001
Family History of CAD - n (%) 550 (22.5) 859 (23.5) 0.37 319 (23.2) 479 (23.8) 0.71 231 (21.7) 380 (23.2) 0.37
Previous STEMI- n (%) 396 (16.2%) 184 (5.0) < 0.001 219 (15.9) 101 (5) < 0.001 177 (16.6) 83 (5.1) < 0.001
Previous PCI – n (%) 500 (20.5) 269 (7.4) < 0.001 276 (20.1) 154 (7.6) < 0.001 224 (21) 115 (7) < 0.001
Previous CABG - n (%) 67 (2.7) 40 (1.1) < 0.001 30 (2.2) 27 (1.3) 0.08 37 (3.5) 13 (0.8) < 0.001
Referral to Primary PCI Hospital
Ambulance (from community) – n (%) 1304 (53.4) 2057 (56.3) 0.027 717 (52.1) 1091 (54.2) 0.25 587 (55.1) 966 (58.9) 0.049
Time delays
Ischemia time, median [25–75th] 200 [130–358] 184 [120–310] < 0.001 200 [1125–330] 180 [120–300] 0.009 210 [135–385] 195 [125–330] 0.006
Total Ischemia time > 12 h – n (%) 270 (11.1) 348 (9.5) 0.051 123 (8.9) 184 (9.1) 0.85 147 (13.8) 164 (10.0) 0.003
Door-to-balloon time, median [25–75th] 40 [25–60] 35 [22–60] < 0.001 38 [25–60] 32 [21–60] 0.006 40 [28–63] 35 [24–60] < 0.001
Door-to-balloon time > 30 min (%)– n (%) 1490 (61.1) 1936 [53] < 0.001 800 (58.2) 1038 (51.6) < 0.001 690 (64.8) 898 (54.8) < 0.001
Clinical Presentation
Anterior STEMI – n (%) 1079 (44.2) 1695 (46.4) 0.093 607 (44.1) 941 (46.7) 0.14 472(44.3) 754 [46] 0.41
Out-of-hospital cardiac arrest – n (%) 134 (5.5) 280 (7.7) 0.001 77 (5.6) 148 (7.3) 0.045 57 (5.3) 132 (8) 0.007
Cardiogenic shock– n (%) 198 (8.1) 314 (8.6) 0.51 118 (8.6) 147 (7.3) 0.17 80 (7.5) 167 (10.2) 0.02
Rescue PCI for failed thrombolysis – n (%) 93 (3.8) 126 (3.4) 0.46 51 (3.7) 73 (3.6) 0.93 42 (3.9) 53 (3.2) 0.34

*Mann-Whitney test

CAD = Coronary Artery Disease; STEMI = ST-segment Elevation Myocardial Infarction; PCI = Percutaneous Coronary Intervention; CABG 0 Coronary Artery Bypass Graft;