Table 2.
Baseline demographic and clinical characteristics according to in-hospital RASI therapy.
| OVERALL POPULATION (N = 5388) |
YEAR 2019 (N = 2877) |
YEAR 2020 (N = 2511) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| RASI (n = 4080) | No RASI (n = 1308) | P value | RASI (n = 2187) | No RASI 2019 (n = 680) | P value | RASI (n = 1883) | No RASI 2020 (n = 628) | P value | |
| Age (median, IQR) | 63 [55–72] | 66 [57–75] | < 0.001 | 63 [55–72] | 67 [57–75] | < 0.001 | 63 [54–71] | 65 [57–75] | < 0.001 |
| Age > 75 year – n. (%) | 795 (19.5) | 338 (25.8) | < 0.001 | 442 (20.1) | 177 (26) | 0.001 | 353 (18.7) | 161 (25.6) | < 0.001 |
| Male gender – n. (%) | 3047 (74.7) | 917 (70.1) | 0.001 | 1603 (73) | 482 (70.9) | 0.30 | 1444 (76.7) | 435 (69.3) | < 0.001 |
| Diabetes Mellitus- n (%) | 872 (21.4) | 310 (23.7) | 0.08 | 465 (21.2) | 176 (25.9) | 0.01 | 407 (21.6) | 134 (21.3) | 0.91 |
| Hypertension- n (%) | 2295 (53.6) | 700 (53.5) | 0.08 | 1256 (57.2) | 377 (55.4) | 0.45 | 1039 (55.2) | 323 (51.4) | 0.11 |
| Hypercholesterolemia - n (%) | 1799 (44.1) | 509 (38.9) | 0.001 | 957 (43.6) | 263 (38.7) | 0.03 | 842 (44.7) | 246 (39.2) | 0.02 |
| Active Smokers– n (%) | 1765 (43.3) | 507 (38.8) | 0.004 | 952 (43.3) | 259 (38.1) | 0.02 | 813 (43.2) | 248 (39.5) | 0.11 |
| Family History of CAD - n (%) | 961 (23.6) | 259 (19.8) | 0.005 | 519 (23.6) | 141 (20.7) | 0.13 | 442 (23.5) | 118 (18.8) | 0.02 |
| Previous STEMI- n (%) | 390 (9.6) | 108 (8.3) | 0.17 | 211 (9.6) | 51 (7.5) | 0.11 | 179 (9.5) | 57 (9.1) | 0.81 |
| Previous PCI – n (%) | 530 (13) | 138 (10.6) | 0.01 | 247 (12.5) | 81 (11.9) | 0.74 | 256 (13.6) | 57 [91] | 0.03 |
| Previous CABG - n (%) | 59 (1.4) | 29 (2.2) | 0.06 | 28 (1.3) | 14 (2.1) | 0.14 | 31 (1.6) | 15 (2.4) | 0.23 |
| Referral to Primary PCI Hospital | |||||||||
| Ambulance (from community) – n (%) | 2247 (55.1) | 682 (52.1) | 0.06 | 1169 (53.2) | 339 (44.9) | 0.14 | 1078 (52.7) | 343 (54.6) | 0.27 |
| Time delays | |||||||||
| Ischemia time, median [25–75th] | 195 [121–330] | 191 [125–330] | 0.76 | 190 [120–313] | 180 [120–289] | 0.18 | 200 [127–345] | 210 [130–380] | 0.36 |
| Total Ischemia time > 12 h – n (%) | 425 (10.4) | 127 (9.7) | 0.50 | 207 (9.4) | 53 (7.8) | 0.22 | 218 (11.6) | 74 (11.8) | 0.89 |
| Door-to-balloon time, median [25–75th] | 35 [25–60] | 40 [25–68] | < 0.001 | 35 [24–60] | 40 [25–68] | < 0.001 | 37 [25–60] | 40 [25–69] | 0.007 |
| Door-to-balloon time | |||||||||
| >30 min– n (%) | 2259 (55.4) | 816 (62.4) | < 0.001 | 1184 (53.9) | 424 (62.4) | < 0.001 | 1075 (57.1) | 392 (62.4) | 0.002 |
| Clinical Presentation | |||||||||
| Anterior STEMI– n (%) | 1922 (47.1) | 554 (42.2) | 0.003 | 1043 (47.5) | 287 (42.2) | 0.02 | 879 (46.7) | 267 (42.5) | 0.07 |
| Out-of-hospital cardiac arrest – n (%) | 226 (5.5) | 122 (9.3) | < 0.001 | 119 (5.4) | 55 (8.1) | 0.02 | 107 (5.7) | 67 (10.7) | < 0.001 |
| Cardiogenic shock– n (%) | 223 (5.5) | 224 (17.1) | < 0.001 | 109 (5) | 106 (15.6) | < 0.001 | 114 (6.1) | 118 (18.8) | < 0.001 |
| Rescue PCI for failed thrombolysis – n (%) | 148 (3.6) | 48 (3.7) | 0.93 | 77 (3.5) | 26 (3.8) | 0.72 | 71 (3.8) | 22 (3.5) | 0.81 |
*Mann-Whitney test
CAD = Coronary Artery Disease; STEMI = ST-segment Elevation Myocardial Infarction; PCI = Percutaneous Coronary Intervention; CABG 0 Coronary Artery Bypass Graft;