Fig 7. Selected genes with cell-type-specific AEI of the Fadista pancreatic islets RNA-seq data.

We selected 4 genes, CELA3A (A), EDARADD (B), INSM1 (C) and CHGB (D), to show their SNP-level p-values of cell-type-specific AEI using the Fadista bulk RNA-seq samples [15]. The input proportion estimates were obtained using MuSiC [14] based on Segerstolpe single-cell reference [16]. Within each cell type, different shapes represent different SNPs of the gene, with red color indicating significant AEI after FDR multiple testing adjustment.