Fig 8. Selected genes with cell-type-specific AEI of both pancreatic islet RNA-seq data.

We selected 3 genes, PVR (A), SSR3 (B) and GNPNAT1 (C), to show their SNP-level p-values of cell-type-specific AEI using two different bulk samples, Fadista et al. [15] and Bunt et al. [27]. For both samples, the input proportion estimates were obtained using MuSiC [14] based on Segerstolpe single-cell reference [16]. Within each cell type, different shapes represent different SNPs of the gene, with red color indicating significant AEI after FDR multiple testing adjustment.