Fig 2. Genome-wide association study of resistance to M. tuberculosis infection in 3 cohorts from Vietnam, France and South Africa.

A) Forest plot of the association between an additive genetic effect of rs17155120 on chromosome region 10q26.2 and resistance to M. tuberculosis infection. Odds ratios and 95% confidence intervals derived from a linear mixed model, P values, sample sizes and frequency of the effect allele (EAF) are reported by individual cohort and for the random effects meta-analysis. B) Manhattan plot showing results from a genome-wide association study between 333 uninfected subjects and 616 infected subjects for 3,967,482 variants (minor allele frequency > 5% and info > 0.8) with an unadjusted additive genetic model. The -log₁₀(P value) for each variant (y-axis) is presented according to its chromosomal position (x-axis, build hg19). The dashed line indicates the genome-wide significant threshold at P = 5 × 10⁻⁸.