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. 2018 Aug 28;29(8):3363–3379. doi: 10.1093/cercor/bhy205

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Figure 3. — Gap junctions and hemichannel antagonists. (A) Spontaneous electrical activity in SP neuron before and after application of gap junction blocker octanol (1 mM). (B) Connexin hemichannel blocker lanthanum (50 μM) inhibits the spontaneous activity in SP neuron. (C) Dose response curve for lanthanum (0, 5, 10, 25, and 50 μM) obtained for each of the 4 parameters used in the analysis of spontaneous depolarizations. (D) 2.5 mM probenecid (PBND) and vehicle DMSO have no effect on the 4 parameters. Octanol (1 mM), lanthanum (50 μM), and lindane (50 μM), each significantly reduced event counts, duration, surface area, and peak amplitude of spontaneous plateau depolarizations.