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. 2019 Apr 3;40(39):3248–3259. doi: 10.1093/eurheartj/ehz175

Figure 4.

Figure 4

Mechanisms of bacterial adhesion in the damage-induced endocarditis model (15 min of damage by a transaortic catheter). (A) Adhesion of Staphylococcus aureus Newman in wild type (Vwf+/+) vs. VWF knockout mice (Vwf−/−), (B) in platelet depleted vs. control mice, and (C) in ancrod treated vs. control mice. (D–F) Adhesion of different S. aureus Newman mutants to damage aortic valves compared with wild type bacteria; (D) Sortase A (ΔsrtA), (E) von Willebrand Factor binding protein (Δvwb), and (F) Clumping factor A (ΔclfA). Results represent log-transformed volumes in single mice. Mean ± standard deviation, *P < 0.05, two-tailed Student’s t-test.