Table 4.
Best multivariable models of observed time intervals.
| Patient Group | Observed Time Interval (Outcome) | Explanatory Variable (Predictor) | Beta | Standard Error | p |
|---|---|---|---|---|---|
| IVT only | Onset-to-door time (ODT) | NIHSS | −1.741 | 0.687 | 0.0118 |
| Limb weakness (HEMIPAR) | −12.608 | 8.161 | 0.1233 | ||
| Speech difficulties (SPEECH) | −18.927 | 7.619 | 0.0135 | ||
| Nausea and/or vomiting (VOMIT) | 31.159 | 11.748 | 0.0084 | ||
| Onset-to-needle time (ONT) | NIHSS | −1.5934 | 0.7575 | 0.036 | |
| Limb weakness (HEMIPAR) | −15.0672 | 8.9026 | 0.092 | ||
| Speech difficulties (SPEECH) | −24.564 | 8.4185 | 0.004 | ||
| Nausea and/or vomiting (VOMIT) | 43.7237 | 13.1284 | 0.001 | ||
| Door-to-needle time (DNT) | Speech difficulties (SPEECH) | −5.163 | 2.737 | 0.060 | |
| VERTIGO | 8.575 | 3.84 | 0.026 | ||
| EVT (±IVT) | Onset-to-needle time (ONT) | Vascular territory—anterior | −24.76 | 12.99 | 0.058 |
| Drooping of the mouth corner (N VII) | −15.76 | 10.43 | 0.132 | ||
| Door-to-needle time (DNT) | Loss of consciousness (COMA) | 22.675 | 6.046 | 0.0002 | |
| Onset-to-groin time (OGT) | Vascular territory—anterior | −47.32 | 16.89 | 0.005 | |
| Door-to-groin time (DGT) | Drooping of the mouth corner (N VII) | −20.794 | 6.015 | 0.0006 |
Beta is the estimated regression coefficient of the multivariable regression model (OLS) that can be interpreted as the population (point) estimate of the difference in the mean time from the reference group (no symptoms, posterior vascular territory). Beta for the NIHSS is the estimate of the marginal (unit) change, i.e., every one-point increase in the NIHSS value is expected to shorten the mean ONT in the IVT group by 1.59 min; EVT, endovascular therapy; IVT, intravenous thrombolysis; NIHSS, National Institutes of Health Stroke Scale.