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. 2021 Mar 9;13(5):1168. doi: 10.3390/cancers13051168

Figure 2.

Figure 2

Down-regulated miRNA in drug resistant cancer cells and tissues. The decreased expression of oncosuppressor miRNAs promote cisplatin resistance. Two miRNA, miR-25-3p and miR-31-3p, have been shown to target SEMA4C (Semaphorin 4C), although in different experimental models. By inhibiting TKT (transketolase), miR-497 prevents the availability of NADPH used for the production of GSH, an important antioxidant molecule. High levels of GSH are fundamental for the ROS detoxification, which are abundantly produced in cancer cells. Color gradation indicate the multiple role of the miRNA target.