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Schematic representation of pH-sensitive hydrogels swelling. Swelling of the hydrogel occurs via ionization of the pendant groups with consequent increase hydrophilic nature of the polymer chains and electrostatic chain repulsion. ECM—extracellular matrix, H+—Hydrogen ions, OH−—Hydroxide ions. The red circles represent the drugs loaded in the hydrogels. Created with BioRender.com (accessed on 15 January 2021).
