Table 1.

Tumor and/or cell type, expression, functional role, target, and potential use as biomarkers of circRNAs of HPV-associated cancers.

circRNA	Tumor/Cell Type	Expression	Functional Role	Target	Potential Biomarker	Reference
hsa_circ_0001946 (CDR1as/CIRS-7)	Cervical cancers and adjacent normal tissues	Up	Oncogene: promotes proliferation, migration, and invasion	miR-7/FAK	Diagnosis, disease progression, and targeted therapy	[104]
hsa_circ8924	Cervical cancers and adjacent normal tissues	Up	Oncogene: promotes migration and invasion	miR-518d-5p/CBX8	Diagnosis, disease progression, and targeted therapy	[105]
hsa_circ_000284(circHIPK3)	Cervical cancer and normal cell lines	Up	Oncogene: promotes proliferation and invasion	miR-506/SNAI2	Diagnosis, and prognosis	[106,107]
hsa_circ_0000263	Cervical cancer and normal cell lines	Up	Oncogene: promotes proliferation, migration and cell cycle, and inhibits apoptosis	miR-150-5p/MDM4	Diagnosis, and treatment	[108]
hsa_circ_0132980 (circSLC26A4)	Cervical cancers and adjacent normal tissues	Up	Oncogene: promotes proliferation and invasion	miR-1287-5p/HOXA7	Disease progression, and targeted therapy	[109]
hsa_circ_0000745	Cervical cancers and adjacent normal tissues	Up	Oncogene: promotes proliferation, migration, and invasion	E-cadherin/Vimentin	Prognosis, and targeted therapy	[110]
hsa_circ_0018289	Cervical cancers and adjacent normal tissues	Up	Oncogene: promotes proliferation, migration, and invasion	miR-497	Early disease detection	[111]
hsa_circ_0101996	Cervical cancer and adjacent normal tissues, and peripheral blood of cervical cancer patients and healthy subjects	Up	Oncogene: activates cancer progression	MAPK signaling	Diagnosis	[112]
hsa_circ_0101119	Cervical cancers and adjacent normal tissues, and peripheral blood of cervical cancer patients and healthy subjects	Up	Oncogene: activates cancer progression	MAPK signaling	Diagnosis	[112]
hsa_circ_0001445 (cSMARCA5)	Cervical cancers and adjacent normal tissues, and cervical cancer and normal cell lines	Up	Oncogene: promotes proliferation, migration, and invasion	miR-432/EGFR/ERK1-ERK2	Disease progression	[113]
hsa_circ_101996	Cervical cancers and adjacent normal tissues	Up	Oncogene: promotes proliferation, migration, and invasion	miR-8075/TPX2	Disease progression	[114]
hsa_circ_0023404	Cervical cancers and adjacent normal tissues	Up	Oncogene: promotes proliferation, migration, and invasion	miR-136/TFCP2/YAP	Targeted therapy	[115]
hsa_circ_0024169	Vaginal carcinoma cell lines	Up	Unknown	Unknown	Unknown	[122]
circE7	Anal cancers and adjacent normal tissues	Up	Unknown	Unknown	Prognosis	[87]
hsa_circ_0055538	Oral cancers and adjacent normal tissues, and tongue cancer cell lines(HPV-negatives)	Down	Tumor suppressor: inhibits proliferation, migration, and invasion, promotes apoptosis	TP53/BCL2/CASP3	Diagnosis, prognosis, and targeted therapy	[154]
hsa_circ_0008309	Oral cancers and adjacent normal tissues, and tongue cancer cell lines (HPV-negatives)	Down	Tumor suppressor: inhibits proliferation, migration, invasion, and EMT	miR-136-5p/miR-382-5p/ATXN1	Diagnosis	[155]
hsa_circ_081069	Oral cancer and adjacent normal tissues, and tongue cancer cell lines (HPV-negatives)	Up	Oncogene: promotes proliferation and migration	miR-665	Diagnosis, and targeted therapy	[148]
hsa_circ_0001821 (circPVT1)	Head and neck cancers and adjacent normal tissues, and pharinx and tongue cancer cell lines (HPV-negatives)	Up	Oncogene: promotes proliferation	miR-497-5p/AURKA/BUB1	Diagnosis, and targeted therapy	[151]
hsa_circ_0001742	Oral cancers and adjacent normal tissues, and tongue cancer cell lines (HPV-negatives)	Up	Oncogene: promotes proliferation, migration, invasion, and EMT	miR-634/RAB1A	Prognosis	[160,161]