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. 2021 Jan 25;371(6531):850–854. doi: 10.1126/science.abf9302

Fig. 3. Antibody escape mutations in circulating SARS-CoV-2.

Fig. 3

For each antibody or antibody combination, the escape score for each mutation is plotted versus its frequency among the 317,866 high-quality human-derived SARS-CoV-2 sequences on GISAID (26) as of 11 January 2021. Escape mutations with notable GISAID frequencies are labeled. The REGN-COV2 cocktail escape mutation E406W requires multiple nucleotide changes from the Wuhan-Hu-1 RBD sequence and is not observed among sequences in GISAID. Other mutations to residue E406 (E406Q and E406D) are observed with low frequency counts, but neither of these mutant amino acids is a single-nucleotide mutation away from W either.