Table 1.
Baseline characteristics according to tertiles of systolic blood pressure.
| Characteristics | 1st Tertile (≤ 118 mmHg) (n = 95) | 2nd Tertile (119–130 mmHg) (n = 95) | 3rd Tertile (> 130 mmHg) (n = 95) | p for trend |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Age, mean±SD, y | 61.7±7.6 | 62.8±8.6 | 64.8±6.6 | 0.007 |
| Male sex, No. (%) | 78 (82.1) | 79 (83.2) | 76 (80.0) | 0.708 |
| Inclusion criteria (may have more than one), No. (%) | ||||
| History of MI | 56 (58.9) | 36 (37.9) | 38 (40.0) | 0.009 |
| History of PCI | 62 (65.3) | 58 (61.7) | 56 (58.9) | 0.372 |
| History of CABG | 22 (23.2) | 22 (23.4) | 24 (25.3) | 0.735 |
| Cardiovascular risk factors, No. (%) | ||||
| Hypertension | 66 (69.5) | 89 (93.7) | 85 (89.5) | <0.001 |
| Diabetes | 26 (27.4) | 26 (27.4) | 30 (31.6) | 0.523 |
| Anthropometric and blood pressure, mean±SD | ||||
| Weight, kg | 90.1±14.8 | 90.1±13.8 | 92.8±14.3 | 0.208 |
| Body mass index, kg/m2* | 30.4±3.9 | 30.2±3.1 | 31.3±3.7 | 0.078 |
| Waist circumference, cm | 105.8±10.8 | 105.5±9.6 | 108.6±10.8 | 0.069 |
| Systolic BP, mmHg | 108.9±7.4 | 123.9±3.4 | 139.9±8.2 | NA |
| Diastolic BP, mmHg | 66.4±6.7 | 73.7±7.2 | 78.8±9.9 | <0.001 |
| Pulse pressure, mmHg | 42.5±6.7 | 50.1±7.6 | 61.1±11.4 | <0.001 |
| Complete blood count, mean±SD | ||||
| WBC, 109 cells/L | 6.6±1.7 | 6.7±2.7 | 6.6±1.8 | 0.986 |
| Monocytes, cells/μL | 517.6±158.6 | 512.7±146.4 | 548.6±184.3 | 0.193 |
| Neutrophils, cells/μL | 4193.9±1454.4 | 4109.3±1448.9 | 4233.1±1604.2 | 0.857 |
| Lymphocytes, cells/μL | 1701.2±554.6 | 1894.6±2140.4 | 1672.0±589.0 | 0.879 |
| Platelets, cells/μL | 194.8±52.8 | 187.8±49.2 | 195.2±51.2 | 0.959 |
| Lipids, mean±SD | ||||
| Total cholesterol, mg/dL a | 151.2±32.8 | 147.3±35.9 | 158.9±39.5 | 0.143 |
| Triglyceride, median [IQR], mg/dL b | 116.5 [77.0,166.0] | 122.0 [79.0,167.0] | 112.0 [84.0,168.0] | 0.880 |
| HDL-C, mg/dL a | 46.0±13.0 | 46.6±12.0 | 48.7±17.3 | 0.195 |
| LDL-C, mg/dL a | 78.5±25.7 | 73.7±25.7 | 83.9±32.7 | 0.193 |
| Biochemical profile, mean±SD | ||||
| Glucose, mg/dL c | 107.8±41.0 | 107.1±31.6 | 106.8±31.3 | 0.847 |
| HbA1c, % (mmol/mol) | 6.2±1.1 | 6.2±0.9 | 6.2±.8 | 0.850 |
| Creatinine clearance (mL/min) | 103.0±29.1 | 100.3±24.7 | 100.4±27.9 | 0.512 |
| hs-CRP | 0.8 [0.3, 2.6] | 0.7 [0.4, 1.8] | 0.9 [0.5, 2.6] | 0.728 |
| Medication, No. (%) | ||||
| Statin | 92 (96.8) | 91 (95.8) | 89 (93.7) | 0.299 |
| Aspirin | 92 (96.8) | 89 (93.7) | 92 (96.8) | 1.000 |
| ACE-I | 49 (51.6) | 50 (52.6) | 58 (61.1) | 0.191 |
| ARB | 15 (15.8) | 19 (20.0) | 17 (17.9) | 0.706 |
| Hydrochlorothiazide | 15 (15.8) | 22 (23.2) | 19 (20.0) | 0.467 |
| Furosemide | 7 (7.4) | 11 (11.6) | 7 (7.4) | 1.000 |
| Calcium channel blocker | 16 (16.8) | 20 (21.1) | 32 (33.7) | 0.006 |
| Beta blockers | 69 (72.6) | 71 (74.7) | 66 (69.5) | 0.628 |
| On any antihypertensive medication, No. (%) | 88 (92.6) | 92 (96.8) | 87 (91.6) | 0.288 |
ACE-I = angiotensin converting enzyme inhibitor; ARB = angiotensin receptor blocker; BP = blood pressure; CABG = coronary artery bypass grafting; HbA1c = hemoglobin A1c; HDL-C = high density lipoprotein cholesterol; hs-CRP = high-sensitivity C-reactive protein; LDL-C = low density lipoprotein cholesterol; MI = myocardial infarction; PCI = percutaneous coronary intervention; WBC = white blood cell count.
a
To convert to SI unit (mmol/L), multiply by 0.0259
b
To convert to SI unit (mmol/L), multiply by 0.0113
c
To convert to SI unit (mmol/L), multiply by 0.0555