TABLE 3.
Cox Proportional Hazards Regression for Time to Death
| Variables | Univariate HR (95% CI) | p | Multivariate HR (95% CI) | p |
|---|---|---|---|---|
| Age | 1.03 (1.02–1.05) | 0.0001 | 1.02 (1.01–1.04) | 0.005 |
| Female | 1.16 (0.65–2.06) | 0.62 | 0.96 (0.52–1.79) | 0.90 |
| Motorcycle or pedestrian accident | 1.12 (0.66–1.89) | 0.68 | 1.20 (0.69–2.08) | 0.52 |
| Injury Severity Score | 1.01 (0.99–1.03) | 0.23 | 1.00 (0.98–1.03) | 0.70 |
| International Mission for Prognosis and Analysis of Clinical Trials score | 1.04 (1.03–1.05) | < 0.0001 | 1.03 (1.01–1.04) | 0.0001 |
| Acute Physiology And Chronic Health Evaluation II score | 1.09 (1.06–1.12) | < 0.0001 | 1.07 (1.03–1.11) | 0.0009 |
| Any hypertonic saline day 1 or 2a | 2.30 (1.47–3.58) | 0.0002 | 1.80 (1.02–3.17) | 0.04 |
| Any mannitol day 1 or 2a | 3.29 (1.84–5.87) | 0.0001 | 2.13 (1.10–4.12) | 0.03 |
| Propensity to receive mannitol | 1.03 (1.02–1.05) | < 0.0001 | 1.02 (1.01–1.04) | 0.006 |
HR = hazard ratio.
aInteraction between mannitol and hypertonic saline p = 0.56.