Table 1:
Patienta and tumor characteristics
| Characteristics | HPV− HNSCC (n = 84) | HPV+ HNSCC (n = 21) | P Valueb |
|---|---|---|---|
| Average age (range), yr | 65 (45–87) | 61 (45–73) | .15c |
| Sex, no. (%) | |||
| Women | 23 (27) | 7 (33) | |
| Men | 61 (73) | 14 (67) | .79d |
| Tumor location, no. (%) | |||
| Oral cavity | 50 (60) | 3 (14) | |
| Oropharynx | 34 (40) | 18 (86) | <.001d |
| T classification according to AJCC 2017, no. (%)f | |||
| T1 | 5 (6) | 1 (5) | |
| T2 | 22 (26) | 6 (29) | |
| T3 | 15 (18) | 3 (14) | |
| T4 | 42 (50) | 11 (52) | 1e |
| N classification according to AJCC 2017, no. (%) | |||
| N0 | 36 (43) | 4 (19) | |
| N1 | 13 (15) | 6 (29) | |
| N2 | 35 (42) | 9 (43) | |
| N3 | 0 (0) | 2 (9) | .012e |
| M classification according to AJCC 2017, no. (%) | |||
| M0 | 77 (92) | 18 (86) | |
| M1 | 1 (1) | 1 (5) | |
| Mx | 6 (7) | 2 (9) | .47e |
| Tumor keratinization, no. (%) | |||
| Present | 65 (77) | 8 (38) | |
| Absent | 19 (23) | 13 (62) | .001d |
| Degree of keratinization, no. (%) | |||
| Keratinizing | 48 (57) | 3 (14) | |
| Focally keratinizing | 17 (20) | 5 (24) | <.001e |
| Nonkeratinizing, no. (%) | 19 (23) | 13 (62) | |
| Histologic differentiation, no. (%) | |||
| Well differentiated | 15 (18) | Not assessablef | |
| Moderately differentiated | 48 (57) | ||
| Poorly differentiated | 21 (25) | ||
| Semiquantitative histologic score, no. (%)g | |||
| Score 1 (most heterogeneous) | 14 (17) | 0 (0) | |
| Score 2 | 8 (9) | 0 (0) | |
| Score 3 | 41 (49) | 7 (33) | .002e |
| Score 4 | 12 (14) | 5 (24) | |
| Score 5 (most homogeneous) | 9 (11) | 9 (43) | |
| Mean proliferation index, MIB-1 (%)h | 49 | 71 | .005c |
| Range in % | 8–90 | 30–95 |
Note:—AJCC indicates American Joint Committee on Cancer.
a
Total patients, 105.
b
P values are indicated for the comparisons between HPV+ and HPV− HNSCCs.
c
Wilcoxon rank sum test.
d
Pearson χ2 test.
e
Fisher test.
f
HPV+ HNSCC was not graded according to AJCC 2017 guidelines.3
g
The semiquantitative histologic score is described in On-line Table 1.
h
Available in 95 histologic samples.