Fig 2.

A, Mean ER1 for the symptomatic JIA, asymptomatic JIA, and control joints. ER1 shows a monopeak profile with an upward slope that starts at 10 minutes 30 seconds at the end of run 8 and clear separation of the curves between 10 minutes 30 seconds and 13 minutes 10 seconds during runs 9 and 10. B, Individual patient profiles for ER1 for the symptomatic JIA joints. C, Individual patient profiles for ER1 for the asymptomatic JIA joints. D, Individual patient profiles for ER1 for the control TMJ joints. These joints exhibit relatively constant enhancement ratios between 0.73 and 5 at all time points. E, Mean ER2 for the symptomatic JIA, asymptomatic JIA, and control joints. Note the clear separation among the 3 groups at all sampling time points with the mean profile for the symptomatic JIA group showing a monopeak profile. Also, the mean profile of the asymptomatic JIA group is higher at all time points than the mean profile for the control group. F, Individual patient profiles for ER2 for symptomatic JIA joints. All but one of the symptomatic joints, patient 8 RT TMJ, pass above the threshold value of normal (0.95) at multiple time points that thus results in correct classification of 10/11 symptomatic joints. G, Individual patient profiles for ER2 for asymptomatic JIA joints. Most profiles stay below the threshold normal value (0.94) while several pass above. H, Individual patient profiles for ER2 for control TMJ joints. The initial ER2 at 1 minute 10 seconds ranges from 0.15 to 0.5, and the end ER2 for this group at 13 minutes 10 seconds ranges from 0.14 to 0.63. The maximum ratio (peak) reached by any single patient at any time point is 0.94 that serves as a threshold value for normal for ER2. I, Mean R for the symptomatic JIA, asymptomatic JIA, and control joints. Note the clear separation among the 3 groups at all sampling time points. The mean profile for the symptomatic JIA group shows a monopeak profile. J, Individual patient profiles for R for the symptomatic JIA joints. Two joints, patient 2 L TMJ and patient 8 R TMJ, never pass above the 1.55 threshold and thus would be misclassified by R as asymptomatic joints. A third joint, patient 8 L TMJ, passes above the threshold only twice that may result in an indeterminate or borderline classification. K, Individual patient profiles for R for the asymptomatic JIA joints. Two of these joints, patient 5 L TMJ and patient 7 L TMJ pass above the normal threshold. L, Individual patient profiles for R for the control TMJ joints. While most of these joints stay below the 1.55 threshold, one joint, patient 12 L TMJ passes above the threshold at 4 time points, that may lead to misclassification of this joint.