Fig 1.

Sample of maps of quantitative MR imaging measures for 1 axial section in a female patient with PPMS (59.5 years of age; disease duration, 8.3 years; EDSS score, 4.0; total focal WM lesion volume on T2, 14.9 mL). Images show maps of the T1 (A), MTR (B), ADC (C), and FA (D). The empty (black) voxels located centrally in the maps of T1 and MTR are voxels excluded from analyses because of insufficient accuracy in determining the local effective B₁ field strength in and close to the CSF. Details of methods are provided in the text.