Table 3:
ROC curve analysis of PCT parameters for early response (tumor volume shrinkage ≥30%) to concomitant chemoradiotherapy
| Value | Criterion | AUC | P | Sensitivity, % | Specificity, % | Positive LR | Negative LR |
|---|---|---|---|---|---|---|---|
| Baseline BF | >70.4 | 0.54 | .4 | 57.3 | 80.0 | 3.0 | 0.6 |
| BF (40 Gy) | ≤74.4 | 0.82 | .03 | 90.0 | 80.0 | 4.4 | 0.2 |
| Baseline BV | ≥5.0 | 0.83 | .01 | 59.5 | 100 | 0.4 | |
| BV (40 Gy) | ≤6.9 | 0.80 | .02 | 90 | 80 | 5.2 | 0.0 |
| Baseline MTT | ≤9.0 | 0.60 | .8 | 71.4 | 60 | 1.8 | 0.5 |
| MTT (40 Gy) | ≤9.2 | 0.83 | .04 | 100 | 60 | 2.4 | 0.0 |
| Baseline PS | >10.0 | 0.63 | .1 | 100 | 60 | 2.2 | 0.0 |
| PS (40 Gy) | ≤12.6 | 0.80 | .06 | 65 | 100 | 0.4 |
Note:—The values of the provided criteria are the cutoff thresholds for predicting the defined early response. The statistically significant values (P ≤.05) are set in boldface italics; the values approaching statistical significance (P = .06) are set in lightface italics. Values for BF are in mL/min/100 g; for BV, mL/100 mL; for MTT, seconds; and for PS, mL/min/100 g.