Fig 2.

Statistical parametric maps comparing the brains of patients with DLB with those with AD. Comparisons based on conventional VBM (left) and VBM-DARTEL (right) are both illustrated. Highlighted areas represent regions in which patients have significantly decreased GM compared with age-matched healthy controls (P < .001, uncorrected). Patients with AD show significant bilateral GM loss in the MTLs. For patients with DLB, the regions in which significant decreases are identified differed between conventional VBM (upper left) and VBM-DARTEL (upper right). While GM decreases are not found in VBM-DARTEL−based comparisons, scattered decreases in the deep brain are identified with conventional VBM.