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In vivo neuroimaging and spectroscopy of hyperpolarized 13C succinate. In confirmation of the role of BBB, the first truly in vivo hyperpolarized 13C spectra arose predominantly from the stroke region of rat brain (left and center) as shown in 2D ultrafast chemical shift imaging (CSI) series (right panel) (Avance, Bruker, Karlsruhe, Germany). PHIP indicates parahydrogen-induced polarization.
